How Long It Takes For The Iodine-125 Particles To Disappear

Radioactive particle implantation, also known as "gamma knife in vivo", is exactly intertissue radiotherapy, which refers to the implantation of radioactive sources into the tumor or nearby tissues invaded by cancer, including lymphatic metastasis and other tissues in the treatment of cancer. 125I seed source belongs to low LET radiation, which has a relatively large biological effect, and the damage to normal tissue is significantly reduced, and the treatment ratio is improved. Iodine-125 particle source is a kind of miniature radioactive source, which is welded into a titanium tube with a diameter of 0.8mm, a length of 4.5mm and a wall thickness of 0.05mm by sealing a φ0.5 ×3.0mm silver rod permeated with iodine-125. It emits C and G rays, and it also emits fluorescent C rays from the silver rod. It has a half-life of 59.43 days. The effective radii were 1.0cm. The effective time in vivo is 120 days.

The principle of radiation seed implantation therapy: Tumor cells are sensitive to radiation because of genetic instability (the tumor itself is caused by genetic defects that cause growth disorder), and the mechanism of repair after injury is not complete. Therefore, the main purpose of radiotherapy is to use the difference between the two to treat tumors without excessive damage to normal tissues. Brachytherapy destroys DNA duplexes through the direct effect of radiation or the indirect effect of free radicals produced. When tumor cells divide, they die because the integrity of their DNA is compromised and they are unable to divide.

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