When is a bone marrow biopsy necessary?

Myelocentesis is often unsuccessful in patients with some diseases, such as myelosclerosis, myelofibrosis (primary and secondary), or myelofibrosis caused by bone marrow metastasis from malignant tumors (breast, lung, prostate, stomach, etc.), as well as some leukemias (e.g. hairy cell leukaemia) and lymphomas. At this time, the use of bone marrow biopsy can make up for the shortage of bone marrow puncture, biopsy samples can not only understand the cellular components of bone marrow, but also can maintain the structure of bone marrow, malignant cells are easier to recognize, convenient for pathological diagnosis. Bone marrow biopsy is also of significance in understanding the amount of bone marrow hematopoietic tissue in aplastic anemia. Abnormal distribution of blasts (ALIP) in bone marrow biopsies is of great significance in the diagnosis of myelodysplastic syndromes. In addition, biopsy is also useful for the determination of bone marrow necrosis or lipopulp.

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