When is a bone marrow biopsy necessary?
Feb 28, 2022
Some diseases such as myelosclerosis, myelofibrosis (primary and secondary), or myelofibrosis caused by bone marrow metastasis of malignant tumors (breast, lung, prostate, gastric, etc.), and some leukemias ( Bone marrow aspiration in patients with hairy cell leukemia) and lymphoma is often unsuccessful. At this time, the use of bone marrow biopsy can make up for the lack of bone marrow aspirate. The biopsy sample is large, which can not only understand the cellular components in the bone marrow, but also maintain the structure of the bone marrow. Malignant cells are easier to recognize, which is convenient for pathological diagnosis. Bone marrow biopsy also has some significance in understanding the amount of bone marrow hematopoietic tissue in aplastic anemia. Abnormal distribution of blasts (ALIP) in bone marrow biopsy tissue sections has important implications for the diagnosis of myelodysplastic syndromes. In addition, biopsy for the judgment of bone marrow necrosis or fatty pulp is also meaningful.
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