I have leukemia, why should I repeat the bone marrow acupuncture during the treatment?

The morphological changes and compositional changes of various components and cells in the bone marrow can be seen through bone puncture. to diagnose the specific cause. Bone perforation is not intended to prove leukemia. Osteotomy is the most basic diagnostic technique in hematology. Also necessary. "Bone puncture" is for the purpose of diagnosis. A puncture needle is used to penetrate the bone marrow cavity, and a small amount of bone marrow is extracted for testing. Some patients mistakenly believe that the extraction of bone marrow fluid by bone marrow puncture will damage the essence of the human body and damage the vitality, and are reluctant to carry out the examination. In fact, the bone marrow fluid required for bone marrow examination is a very small amount, generally about 0.1ml, while the normal amount of bone marrow fluid in the human body is about 2600ml. It can be seen that the bone marrow fluid extracted during bone marrow biopsy is insignificant compared with the total amount of the human body. What's more, there is a lot of cell regeneration in the body every day. In addition, patients often think that the bone marrow biopsy is very painful and has a sense of fear, in fact, this is unnecessary. "Bone puncture" does not have any danger, and will not leave any Sequelae. Some diseases, especially some blood diseases, are difficult to diagnose without this test. If the condition requires it, it should be done without hesitation. Even if the bone marrow does not have any lesions, it is a great gain, because the exclusion of blood diseases can not only It can relieve the mental burden, and also relieve the pain and possible side effects of patients and their families receiving unnecessary treatment. Although leukemia has undergone a lot of research work, the etiology of leukemia has not been fully understood. At present, it is believed to be related to the following factors: 1. Virus Factors: As early as the 1950s, it was discovered that a mouse leukemia virus can cause mouse leukemia after infecting newborn suckling mice. Therefore, people have always suspected that human leukemia can also be caused by viruses, but there has been no definite conclusion for a long time. Until recently, a major breakthrough has been made in the etiology of leukemia viruses in humans. The leukemia-causing effects of RNA tumor viruses in mice, cats, chickens and cattle have been confirmed, and leukemias caused by such viruses are mostly T-cell types. Human T-cell leukemia virus (HTLV), a type C retrovirus, was isolated from adult T-cell leukemia and lymphoma patients. Antibodies against HTLV structural proteins were also found in the serum of Japanese T-cell leukemia patients. There is no clear relationship between such viruses and childhood leukemia. 2. Chemical factors: some chemical substances have the effect of causing leukemia. The incidence of leukemia in people who are often exposed to benzene and its derivatives is higher than that in the general population. Such as dibenzoanthracene, phenylpyrene etc. can induce leukemia in mice. The reports of nitrosamines, phenylbutazone and its derivatives, chloramphenicol and other induced leukemia can also be seen, but there is a lack of statistical data. Some anti-tumor cytotoxic drugs such as nitrogen Mustard, cyclophosphamide, procarbazine, VP16, VM26, etc. are all recognized to have leukemia-causing effects. Leukemia caused by chemical substances is mostly acute non-leukemia. Before leukemia occurs, there is often a pre-leukemia stage. It is often manifested as pancytopenia. 3. Ionizing radiation: There is solid evidence that various ionizing radiation conditions can cause human leukemia. The occurrence of leukemia depends on the dose of radiation absorbed by the human body, and the whole body or part of the body is exposed to moderate or large doses of radiation. It can induce leukemia after a long time. However, it is still uncertain whether a small dose of radiation can cause leukemia. After the atomic bombs in Hiroshima and Nagasaki, Japan, the incidence of leukemia in severely irradiated areas The morbidity rate is 17 to 30 times that in unirradiated areas. Three years after the explosion, the incidence of leukemia increased year by year, reaching a peak in 5 to 7 years. It was not until more than 20 years later that the incidence rate returned to a level close to that of the whole of Japan. This is the most direct evidence that radiation can cause human leukemia. The incidence of leukemia among radiologists and those who are often exposed to radioactive substances is also several times higher than that of normal people. Frequent radiation diagnosis and treatment can lead to an increase in the incidence of leukemia, which also proves that radiation does cause leukemia. 4. Genetic factors: In recent years, studies have confirmed that abnormal numbers such as increase or decrease in the number of chromosomes, as well as structural abnormalities such as translocations, inversions, and deletions, make the structure and expression of genes abnormal. Gene expression or gene inactivation is one of the foundations of cell malignant transformation. People with chromosomal aberrations have a higher incidence of leukemia than normal people. For example, the incidence of leukemia in children with trisomy 21 is 1/74 within the age of 10, the incidence of Bloom syndrome is 1/3 within the age of 26, and the incidence of Fanconi (congenital aplastic anemia) syndrome is 21 years old. The incidence rate is 1/12. Some people have statistically analyzed the situation of several leukemia patients in the same family, and believe that there may be genetic factors. When a member of the family develops leukemia, the probability of his close relatives developing leukemia is higher than that of ordinary people. 4 times higher. Leukemia is also more likely to occur in some congenital hereditary diseases such as congenital stupidity. In identical twins, one party develops leukemia, and the other party has a 25% chance of developing leukemia. These examples all illustrate the possibility of genetic factors in the pathogenesis of leukemia. 5. Other blood diseases: some blood diseases may eventually be found to be acute leukemia, such as chronic myeloid leukemia, polycythemia vera, essential thrombocythemia, myelofibrosis, myelodysplastic syndrome, paroxysmal nocturnal hemoglobin Urine, lymphoma, multiple myeloma, etc. In general, the onset of leukemia is the result of a complex multi-factorial effect. Genetic qualities, viruses, radiation, and chemical substances may interact with each other and overlap to lead to the occurrence of leukemia.

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