Does bone marrow puncture needle normal mean no myeloma and blood disease

We can do immunohistochemistry to see where the tumor cells originated in the bone marrow. If hematuria is also negative for the M protein, there is less chance of myeloma. Bone marrow puncture needle and biopsy are generally anastomosed, but to explain the problem of each focus, but there will be inconsistent. Because puncture material is less, biopsy can better reflect the tissue structure of bone marrow.