What Does A Liver Biopsy Tell Us?

The value of liver biopsy has the following eight points:

1. It is beneficial to the differential diagnosis of various liver diseases

Many clinical diagnosis can be difficult to chronic liver disease, such as various types of viral hepatitis, alcoholic hepatitis, liver TB, liver cancer, liver granuloma, schistosomiasis, fatty liver, liver abscess, primary biliary cirrhosis, and various metabolic liver disease (liver degeneration, liver glycogen accumulating disease, hepatic amyloidosis), etc., often by liver biopsy is required to understand the patient's liver lesions, Provides important and possibly definitive evidence for a definite diagnosis.

2. Understand the extent and activity of liver lesions

Liver biopsy is a kind of examination method which can directly understand the pathological changes of liver tissue and make more objective and accurate diagnosis. Have MANY CHRONIC HEPATITIS B PATIENT, INFECTION LIVER DISEASE VIRUS TIME IS VERY LONG, BUT DRAW BLOOD ASSAY TO DISCOVER TRANSAMINASE ABNORMALITY MAY HAVE ONLY HALF A YEAR TIME, LIVER DISEASE VIRUS CONTENT LEVEL IS NOT TALL ALSO. In such patients, liver puncture can find out whether the chronic liver disease is in the active stage and infer the severity of the lesion.

3. Provide the basis for the etiological diagnosis of various types of viral hepatitis. Most hepatitis viruses are hepatotropic viruses, which are often parasitic in liver tissues. Only when serum liver disease virus reaches a certain amount, clinical assay can detect. So AT present STILL HAVE HEPATITIS OF A FEW VIRUS, CLINICAL ASSAY SHOWS MARKER OF virus OF SERUM liver disease IS NEGATIVE ENTIRELY, DETERMINE ITS PATHOGEN HARD. However, by liver puncture, hypersensitive immunohistochemistry and in situ molecular hybridization, hepatitis virus can be detected in liver tissue.

4. Detection of early, quiescent or compensated cirrhosis cirrhosis, especially liver fibrosis, is generally difficult to detect by blood test and B-ultrasound examination in the early stage of the disease. However, liver biopsy provides a precise diagnosis of liver fibrosis and early-stage, quiescent, or compensatory cirrhosis, and enables the differentiation of clinical types of cirrhosis, from alcoholic cirrhosis to posthepatitic cirrhosis, and whether it is accompanied by active hepatitis. For example, some patients diagnosed as carriers of chronic asymptomatic liver disease may be found to have active cirrhosis or chronic active hepatitis by liver biopsy.

5. It is conducive to drug selection and drug efficacy judgment

The pathological changes of liver biopsy before and after treatment are reliable indicators to evaluate the effect of drug therapy, and provide objective evaluation basis for clinical drug therapy. At present THE drugs THAT COMMONLY USED TO FIGHT liver disease VIRUS HAVE INTERFERon AND LAMivudINE, APPLY interferON OR LAMivUDINE TO UNDERTAKE ANTIVIRAL treatment, not only the course of treatment is long, and the price is expensive. If liver puncture can be performed before treatment, antiviral drugs can be used selectively and pertinently according to the degree of inflammation activity in liver tissue, which will significantly improve the curative effect.

6. Identify the nature and cause of jaundice

Clinical jaundice is often difficult to determine the cause of liver biopsy. It can determine whether the jaundice is a disorder of bilirubin metabolism, or hepatocellular jaundice, or caused by cholestasis, whether it is viral or drug-induced. Different etiology, prognosis and treatment are completely different, only the diagnosis is clear, can make the correct diagnosis and treatment plan.

7. As the evaluation index of chronic hepatitis condition and prognosis

Liver puncture can find the pathological changes of liver tissue, and provide an objective basis for the judgment of disease changes and prognosis. Severe hepatitis, such as hepatocyte edema, is mild, the prognosis is good, and the mortality is low. If hepatocyte necrosis is the main cause, and the residual rate of normal hepatocytes is low, the disease is serious, the prognosis is poor, and the mortality is high.

8. Diagnostic treatment is available

Under the guidance of B-mode ultrasound or CT, purposeful liver puncture can be performed to discharge pus from liver abscess, inject drugs, and treat liver cancer by anhydrous alcohol intratumoral injection. At the same time of puncture sampling and diagnosis, diagnostic treatment can also be carried out to ensure the balance between diagnosis and treatment.

The incidence of hemorrhage after liver biopsy is about 1 in 100,000. As the liver biopsy technology is very mature, the operation of liver biopsy can be foolproof as long as the indications and contraindications are well mastered and adequate preparation is made before liver biopsy.

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