Why do you need a bone marrow biopsy?

A bone marrow biopsy, or bone-marrow biopsy, involves taking a small cylindrical piece of bone marrow, about 0.5 to 1 cm long, with a special needle for pathological examination. The operation method is basically the same as that of bone marrow puncture. The material removed retains the integrity of bone marrow tissue structure, which can make up for the deficiency of bone marrow puncture. Has the following advantages:

1) Keep the natural structure of hematopoietic tissue, so as to judge the proportion of red pulp and adipose tissue;

2) A comprehensive understanding of the degree of myelodysplasia, density and distribution of nucleated cells;

3) It can avoid the dilution of sinusoidal blood;

4) It can help diagnose myelofibrosis, hair-cell leukemia, bone marrow necrosis and bone marrow adipose degeneration. It can prompt the transformation of myelodysplastic syndrome to acute myelogenous leukemia, and has differential effect on "dry pumping". Therefore, bone marrow biopsy can not only understand the composition of bone marrow cells and distribution of primitive cells, but also observe the cell morphology, which is convenient for pathological diagnosis and provides an important diagnostic basis for diseases that are difficult to be diagnosed, such as aplastic anemia, myelodysplastic syndrome, bone marrow puncture and dry aspiration.

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