Why Do Liver Needle Biopsy?

1. Assist in the diagnosis and identification of various liver diseases: clinically, many acute and chronic liver diseases are difficult to diagnose, such as various types of viral hepatitis, alcoholic hepatitis, fatty liver, liver granuloma, liver tumor, liver abscess, liver tuberculosis, Clinical fluke disease, primary biliary cirrhosis and various metabolic liver diseases (hepatolenticular degeneration, hepatic glycogen storage disease, hepatic amyloidosis), etc. Liver puncture can be used to understand the patient's liver disease, which is liver disease diagnosis provides important clues.

2. Provide the etiological diagnosis of various types of viral hepatitis: Most of the hepatitis viruses are hepatotropic viruses, and they are often parasitic in the liver tissue. At present, there are still some viral hepatitis, and its pathogen is difficult to be identified by clinical tests. However, by liver puncture, with ultrasensitive immunohistochemistry and in situ molecular hybridization, the hepatitis virus parasitic in liver tissue can be detected.

3. Understand the degree and activity of liver lesions: Clinically, there are many patients with chronic hepatitis B who have been infected with hepatitis B virus for a long time, but it may only be half a year for abnormal transaminase detected by blood test, and the level of hepatitis B virus load is not high. high. In such patients, liver biopsy can directly understand the pathological changes of liver tissue, find out whether the chronic liver disease is in the active stage, and infer the severity of the disease, so as to make a more objective and accurate diagnosis.

4. Detection of early, static or compensated liver cirrhosis: For early liver fibrosis, it is generally difficult to detect through blood tests, B-ultrasound or CT or MRI examinations. However, liver biopsy can accurately diagnose liver fibrosis and liver cirrhosis in the early, static or compensated stage, and help to identify the etiology of liver cirrhosis and distinguish post-hepatitis cirrhosis, alcoholic cirrhosis, or liver cirrhosis. Metabolic disease and whether it is accompanied by active hepatitis, etc.

5. It is beneficial to the selection of drugs and the judgment of drug efficacy: the pathological changes of liver biopsy before and after treatment are reliable indicators for evaluating the efficacy of drug treatment. The application of antiviral drugs will significantly improve the efficacy. In addition, we found that some hepatitis patients had a history of many years, but the inflammation was very mild through liver biopsy, and only G1-G2 was evaluated by the GS system, which did not meet the standard of antiviral treatment. At this time, clinical observation can be performed without spending unnecessary money. In addition, any drug must be metabolized by the liver, which increases the burden on the liver.

6. As an evaluation index for the condition and prognosis of chronic hepatitis: Liver puncture can detect the pathological changes of liver tissue, and provide an objective basis for the judgment of disease changes and prognosis. The severity of severe hepatitis is directly related to the degree of hepatocyte necrosis. Through liver puncture, if the pathology shows that the liver tissue is dominated by hepatocyte edema, the condition is mild, the prognosis is better, and the mortality rate is low; if the main liver cell necrosis is necrosis, and the residual rate of normal hepatocytes is low, the condition is serious , the prognosis is poor, and the mortality rate is high.

7. Identify the cause of jaundice: The patient has jaundice. After medical history, clinical laboratory examination, and imaging examination, the cause of jaundice cannot be determined. Liver biopsy can determine whether the jaundice is hepatocellular jaundice or cholestasis. Caused by sex, whether it is viral or drug-induced, or caused by bilirubin metabolism disorders. Liver puncture is used to identify the cause, guide the treatment, and understand the prognosis.

8. Diagnostic treatment is possible: with ultrasound intervention, purposeful liver puncture, liver abscess puncture and pus extraction, drug injection, intratumoral injection of anhydrous alcohol, radiofrequency ablation for liver cancer, etc. can be performed. At the same time of puncture, sampling and diagnosis, diagnostic treatment can also be carried out, so that both diagnosis and treatment are correct.

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