Significance of bone marrow biopsy in aplastic anemia

When aplastic anemia occurs, bone marrow smear and bone marrow biopsy are two very important items for the diagnosis of aplastic anemia. Usually, in patients with aplastic anemia, a decrease in the uniformity of hematopoietic tissue can be found during bone marrow biopsy.

In the bone marrow smear, it can be found that bone marrow hyperplasia is reduced or severely reduced. In the bone marrow, the myeloid, erythroid and megakaryocyte lineage can be reduced, and the proportion of lymphocytes can often be increased, and sometimes non-hematopoietic cells can also appear. The cell mass, the so-called non-hematopoietic cell mass, is usually composed of lymphocytes, plasma cells, reticulocytes and other non-hematopoietic cells.

If there is a non-hematopoietic cell mass in the bone marrow smear, and there is a decrease in the homogeneity of the hematopoietic tissue in the bone marrow biopsy, it is a very good basis for the diagnosis of aplastic anemia.

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