How is bone marrow hematopoietic stem cell collection performed?

Bone marrow hematopoietic stem cells are harvested directly from red bone marrow. Red bone marrow is the main site of hematopoietic stem cells. As the blood in the marrow cavity will also be drawn at the same time, to prevent the donor from losing too many red blood cells and causing anemia or low blood pressure. Prior to bone marrow donation, the donor must make an autologous blood supply: a total of 600 ml of blood is collected gradually several weeks before donation, stored outside the body and transfused during surgery. Bone marrow hematopoietic stem cell collection is performed surgically under general or epidural anesthesia. After anesthesia, needles are inserted into the iliac crest on either side of the hip to extract bone marrow cells. Along with the extraction of bone marrow cells, multiple punctures of the iliac crest are possible. The amount of bone marrow withdrawn depends on the body weight of the patient. Approximately 500~1000 ml of bone marrow fluid should be withdrawn. The operation at the same time to the body back to the original blood, so as to avoid anemia. Bone marrow hematopoietic stem cell collection does not cut into the skin, but leaves several puncture holes on the skin surface. Postoperative bleeding at the wound site should be prevented. Pain may be felt at the wound site and can be treated symptomatically. Most donors also experience a sore lower back. In addition, because of the anesthetic effect, some donors will have nausea and vomiting feelings. Because the white blood cell count is temporarily low, you may have a mild fever. These conditions can also be treated by a doctor.

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