Does fatty liver require liver biopsy?

Liver biopsy is the most accurate examination item to check the degree of liver damage, but there are not many liver biopsy for fatty liver now. Many patients with fatty liver believe that liver biopsy is not necessary for fatty liver. In fact, if you want a more accurate examination, it is best to perform a liver biopsy. Many fatty liver patients only undergo blood biochemical tests or imaging tests. Although these are of great significance for the diagnosis of fatty liver, liver biopsy is the gold standard for the diagnosis of fatty liver. 1. Why do you need liver puncture for fatty liver? Liver puncture is the abbreviation of liver biopsy. It is based on the principle of negative pressure suction and uses a rapid puncture method to extract a small amount of liver tissue from the liver. The morphological changes of liver tissue and immune factors were observed directly under the microscope, and then combined with clinical data, the diagnosis of the disease was made. At the same time, in addition to fatty liver, including hepatitis B, liver cirrhosis, etc., it is best to perform liver biopsy. If the metabolic function of liver fat is disturbed and the balance is out of balance, resulting in the accumulation of fat in the liver, if its weight exceeds 5% of the liver weight (wet weight). Or when more than 30% of the liver has steatosis and is diffusely distributed in the whole liver, it can be called fatty liver. The diagnostic value of liver biopsy is much higher than that of blood biochemistry and imaging examination. It is the only method to diagnose fatty liver, steatohepatitis and liver fibrosis. Symptoms of liver fibrosis, and can prompt the cause of fatty liver and understand the situation after recovery. 2. Fatty liver biopsy can be divided into two types: vesicles and macrobubbles according to the diameter of intracellular lipid droplets in liver cells; according to the degree of steatosis of liver cells under the light microscope of HE staining of liver biopsy tissue, it can be divided into two types. Fatty liver is divided into mild, moderate and severe. 3. Precautions for liver biopsy Because the operation of liver biopsy is invasive, it is generally difficult for patients to accept it. In fact, it has been more than 100 years since the German Paul Ehrlicl first applied liver biopsy to the clinic in 1883. With the continuous improvement of puncture instruments and operation methods, the simplification of steps, the shortening of time, and the improvement of safety performance, Liver biopsy is also gaining popularity. Patients usually need local anesthesia, and the negative pressure suction puncture technique is used to perform percutaneous puncture under the positioning and guidance of B-ultrasound and CT. The method is convenient and safe, and has a high success rate. 4. Contraindications of liver puncture Not all patients can undergo liver puncture examination. Before liver puncture, patients need to perform a series of tests, such as PT, platelet count and coagulation time, B-ultrasound or CT, etc., to understand liver puncture the purpose, method, and possible complications. ? If the blood pressure is found to drop after liver puncture, the boss will panic. If your pulse is fast, you should seek medical attention immediately without delaying the treatment. After liver puncture, some patients will have transient pain in the liver area or at the site of liver puncture, but the reaction is mild and does not require treatment, and can be relieved spontaneously after 24 hours.

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