Bone biopsy for morphological examination of bone marrow cells is mainly used for:
Mar 18, 2022
1. Confirm the diagnosis of certain hematopoietic or non-hematopoietic diseases
Most of these diseases have characteristic cytomorphological changes, and bone marrow examination has a decisive role in diagnosis. Such as various types of leukemia, malignant histiocytosis, multiple myeloma, bone metastases, aplastic anemia, megaloblastic anemia, typical iron deficiency anemia, etc. In addition, the discovery of some special cells, such as tuberculosis multinucleated giant cells, Hodgkin's disease cells or certain parasites such as Plasmodium, kala-azar bodies, etc., can also be diagnosed accordingly.
2. Auxiliary diagnosis of certain hematopoietic system diseases
Most of these diseases are mainly based on changes in bone marrow hematopoietic function, and the results of bone marrow examinations need to be comprehensively analyzed in combination with other clinical data before a diagnosis can be made. Such as hemolytic anemia, thrombocytopenic purpura, myelodysplastic syndrome and so on.
3. Application as differential diagnosis
In clinical cases of unexplained fever, lymph node, liver or spleen enlargement, bone pain or arthralgia, etc., bone marrow examination can help to identify whether it is caused by hematopoietic system diseases.
Bone marrow examination should be contraindicated in patients with severe bleeding such as hemophilia due to deficiency of coagulation factors.
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