Franseen Needles

Given the poor outcomes of traditional chemotherapy, there is increased focus on molecular profiling so that pancreatic cancer treatment can be personalised. Pancreatic tissue with architecture containing both tumour cells and desmoplastic stroma is pivotal for molecular analysis. Although EUS-FNA is diagnostically accurate, the cytological aspirate is suboptimal for DNA sequencing. Therefore, clinical trials evaluating personalised treatment in pancreatic cancer prefer tissue procurement via percutaneous or surgical biopsies over EUS-FNA. Recently, a three-plane symmetric needle with Franseen geometry has been developed for performing EUS-guided FNB. The large crown-tip with three cutting edges and long insertion length were postulated to facilitate histological tissue procurement. We conducted a randomised trial comparing tissue acquisition between the 22-gauge (G) Franseen biopsy (Acquire, Boston Scientific) and 22G standard bevel FNA (Expect, Boston Scientific) needles in patients undergoing EUS-guided sampling of pancreatic masses.

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