FNA Needles FNB Needles

In this study, in order to prove true histological tissue procurement, we used specialised imaging software to quantify individual tissue components. Our observations proved that the study hypothesis was correct: the Franseen biopsy needle yielded high-quality histology samples significantly more often than the standard FNA needle. Histological architecture was retained, and the total tissue and tumour yield from the FNB needles were 20 and 7 times greater, respectively, than that procured using FNA needles from the same lesion. Furthermore, desmoplastic fibrosis was seen in 85% of FNB samples compared with only 33% in the FNA cohort. Desmoplasia is an expected cellular reaction to a neoplastic process but is difficult to procure using standard bevel FNA needles as it requires ‘coring’ of the tissue. This is particularly relevant in clinical trials because patients with pancreatic cancer with activated stroma tend to have a poor prognosis and are less likely to benefit from neoadjuvant therapy. Two of the 10 samples in this study tested positive for K-ras G12D mutation, which is an independent prognostic marker for advanced ductal adenocarcinoma with poor response to gemcitabine-based chemotherapeutic regimens.

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